COURTESY REMINDERS AND ALERTS

Courtesy Reminders are provided as an additional precaution for monitoring patients.  They contain information about any procedures, actions, or Prescribing Information requirements that may be appropriate.

Alerts are provided when it is determined by the Clozapine Prescription Access System (CPAS) that a safety issue related to the program and defined by the Clozapine Prescribing Information may have occurred.

It is not the intention of CPAS to define, determine, or influence a physician’s or pharmacist’s care of the patient.  The intent is only to provide additional patient information for participating healthcare providers.  Courtesy Reminders and Alerts will be prompted by:

EVENT	REMINDER/ALERT	GENERATED WHEN	SENT TO
Change in monitoring frequency	Reminder A	A patient is eligible for every 2 weeks monitoring	Pharmacist
	Reminder A4	A patient is eligible for every 4 weeks monitoring	Pharmacist
Significant drop in WBC or ANC	Reminder C	A single drop, or cumulative drop within 3 weeks, of WBC ≥ 3000/mm3 or ANC ≥ 1500/mm3 occurs	Pharmacist
Discontinuation of therapy	Reminder D	A patient’s status is modified to discontinued	Pharmacist and Physician
Late WBC and ANC Reports	Reminder E	Reports are not received for active patients.	Pharmacist
Non-rechallengeable	Reminder G	A patient’s status is modified to non-rechallengeable	Pharmacist and Physician
Mild leukopenia/ granulocytopenia	Alert A	3500/mm3 > WBC ≥ 3000/mm3 and/or 2000/mm3 > ANC ≥ 1500/mm3	Pharmacist and Physician
Moderate leukopenia/ granulocytopenia	Alert B	3000/mm3 > WBC ≥ 2000/mm3 and/or 1500/mm3 > ANC ≥ 1000/mm3	Pharmacist and Physician
Severe leukopenia/ granulocytopenia	Alert C	WBC < 2000/mm3 and/or ANC < 1000/mm3	Pharmacist and Physician
Late discontinued WBC and ANC reports	Alert D	Reports are not received for discontinued patients	Pharmacist and Physician
Late non-rechallengeable WBC and ANC reports	Alert G	Reports are not received for non-rechallengeable patients	Pharmacist and Physician
Dispensing of clozapine to a non-rechallengeable patient	Alert H	Active WBC and ANC reports are received for non-rechallengeable patients	Pharmacist and Physician

To Print a PDF file of the Courtesy Reminders and Alerts table click here.

TELEPHONE REMOTE ACCESS DATA ENTRY

Automated telephone remote access allows registered healthcare providers to review the previous WBC count and ANC value of registered patients and to confirm patient reclearance codes.  This secure method of communication will also allow healthcare providers to enter all of the information contained on the WBC Count and ANC Reporting Forms C, D, and E.

SECURE ON-LINE ACCESS

Healthcare providers registered with CPAS can receive a username and password to access or report WBC count and ANC information for their patients treated with The Mylan Brand of Clozapine.   Access to this secure area of the website will allow healthcare providers to report every week, every 2 weeks or every 4 weeks WBC counts and ANC values, review patient files including the entire history of WBC counts and ANCs, dosage information, and confirm patient reclearance codes.

On-Line Access (user account required)